SCHEMBL10499028

SCHEMBL10499028

CCCCN1CCN(c2ccc(N)cc2)C1=O

nearest known ligand 0.56

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 8/20 0.56
S1PR1 P21453 1/20 0.54
DRD2 P14416 6/20 0.50
DRD3 P35462 5/20 0.50
HDAC1 Q13547 2/20 0.46
RAB9A P51151 1/20 0.44
KCNH2 Q12809 1/20 0.44
GRM2 Q14416 1/20 0.44
CYP19A1 P11511 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3710958 0.90 DRD2 (0.52) CYP1A1S1PR1DRD2DRD3HDAC1
SCHEMBL10498437 0.83 RAB9A (0.49) CYP1A1S1PR1DRD2DRD3HDAC1
SCHEMBL10498419 0.81 CYP1A1 (0.54) CYP1A1S1PR1DRD2DRD3HDAC1
SCHEMBL10498818 0.81 S1PR1 (0.52) CYP1A1S1PR1DRD2DRD3HDAC1
SCHEMBL8686095 0.80 S1PR1 (0.60) CYP1A1S1PR1DRD2DRD3RAB9A
SCHEMBL10498393 0.79 CYP1A1 (0.64) CYP1A1S1PR1DRD2DRD3HDAC1
SCHEMBL4670487 0.79 DRD2 (0.45) CYP1A1S1PR1DRD2DRD3HDAC1
SCHEMBL7828106 0.76 CYP1A1 (0.64) CYP1A1S1PR1DRD2DRD3RAB9A
SCHEMBL8787666 0.76 CYP1A1 (0.64) CYP1A1S1PR1DRD2DRD3RAB9A
SCHEMBL14698020 0.76 DRD2 (0.65) CYP1A1S1PR1DRD2DRD3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4861879-A VAGINAL FUNGICIDE JANSSEN PHARMACEUTICA N.V. (BE) 1989-08-29 US disclosed
EP-0118138-B1 ((4-(4-(4-PHENYL-1-PIPERAZINYL)PHENOXYMETHYL)-1,3-DIOXOLAN-2-YL)METHYL)-1H-IMIDAZOLES AND 1H-1,2,4-TRIAZOLES JANSSEN PHARMACEUTICA N.V. (BE) 1989-06-14 EP disclosed
US-4735942-A FUNGICIDE, BACTERICIDE PARTICULARLY FOR UROGENITAL DISORDERS JANSSEN PHARMACEUTICA, N.V. (BE) 1988-04-05 US disclosed
US-4619931-A BACTERICIDES, FUNGICIDES JANSSEN PHARMACEUTICA, N.V. (BE) 1986-10-28 US disclosed
EP-0118138-A1 ((4-(4-(4-Phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazoles and 1H-1,2,4-triazoles JANSSEN PHARMACEUTICA N.V. (BE) 1984-09-12 EP disclosed