Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | F3 | P13726 | 1/20 | 0.45 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501143 | 1.00 | ALDH1A1 (0.46) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| SCHEMBL10500625 | 0.86 | ALDH1A1 (0.44) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| SCHEMBL10500615 | 0.86 | ALDH1A1 (0.44) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| SCHEMBL13588765 | 0.84 | ALDH1A1 (0.55) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| SCHEMBL7989661 | 0.81 | ALDH1A1 (0.56) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| SCHEMBL7989658 | 0.81 | ALDH1A1 (0.56) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| SCHEMBL10501466 | 0.81 | MAOA (0.41) | ALDH1A1GAAMAPTHTTTP53 | |
| SCHEMBL10501458 | 0.81 | MAOA (0.41) | ALDH1A1GAAMAPTHTTTP53 | |
| SCHEMBL2784997 | 0.74 | ALDH1A1 (0.71) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| SCHEMBL29993557 | 0.73 | ALDH1A1 (0.59) | ALDH1A1GAAAPPHCAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170214-B1 | THE PREPARATION OF 1,3-DIHYDRO-4-PYRIDOYL-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-13 | — | — | EP | disclosed |
| US-4803278-A | Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0170214-A1 | The preparation of 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-05 | — | — | EP | disclosed |