SCHEMBL10501432

SCHEMBL10501432

NC(C=O)C(O)c1cccnc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.49
TSHR P16473 1/20 0.45
SLC6A2 P23975 3/20 0.43
SLC6A4 P31645 3/20 0.43
SLC6A3 Q01959 3/20 0.43
CFTR P13569 1/20 0.43
GOPC Q9HD26 1/20 0.43
LMNA P02545 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
GRM8 O00222 1/20 0.42
GRM4 Q14833 1/20 0.42
GAA P10253 1/20 0.41
CYP17A1 P05093 1/20 0.41
KCNA5 P22460 3/20 0.41
KCNN4 O15554 2/20 0.39
CYP19A1 P11511 1/20 0.39
CYP3A4 P08684 2/20 0.38
CYP2D6 P10635 2/20 0.38
KCNH2 Q12809 2/20 0.38
F7 P08709 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28087641 0.82 SMN1; SMN2 (0.52) SMN1; SMN2TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL27273877 0.79 SMN1; SMN2 (0.45) SMN1; SMN2TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL27266930 0.79 SMN1; SMN2 (0.41) SMN1; SMN2TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL6822525 0.78 CFTR (0.48) SMN1; SMN2TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL30255476 0.78 SMN1; SMN2 (0.55) SMN1; SMN2TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL12598166 0.77 ADRA2A (0.54) SLC6A2SLC6A4SLC6A3LMNACYP2D6
SCHEMBL4143616 0.77 ADRA2A (0.54) SLC6A2SLC6A4SLC6A3LMNACYP2D6
SCHEMBL25269606 0.77 LMNA (0.59) SMN1; SMN2TSHRSLC6A2SLC6A4SLC6A3
SCHEMBL14944868 0.77 LMNA (0.59) SMN1; SMN2TSHRSLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL15547862 0.77 CFTR (0.47) SMN1; SMN2TSHRSLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1917020-B1 MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS SEATTLE GENETICS INC (US) 2016-05-25 EP disclosed
WO-2007008603-A1 MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS SEATTLE GENETICS, INC. (US) 2007-01-18 WO disclosed
EP-0170214-B1 THE PREPARATION OF 1,3-DIHYDRO-4-PYRIDOYL-2H-IMIDAZOL-2-ONES MERRELL DOW PHARMACEUTICALS INC. (US) 1989-09-13 EP disclosed
US-4803278-A Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones MERRELL DOW PHARMACEUTICALS, INC. (US) 1989-02-07 US disclosed
EP-0170214-A1 The preparation of 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones MERRELL DOW PHARMACEUTICALS INC. (US) 1986-02-05 EP disclosed