Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 6/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143616 | 1.00 | ADRA2A (0.54) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL18973797 | 0.88 | ACP3 (0.43) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL13207809 | 0.79 | CHRNA7 (0.39) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL13995142 | 0.79 | CHRNA7 (0.39) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL10189483 | 0.78 | KDM4E (0.54) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL11789068 | 0.78 | KDM4E (0.54) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL10501432 | 0.77 | SMN1; SMN2 (0.49) | LMNASLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL12919029 | 0.77 | ALDH1A1 (0.47) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL14198484 | 0.77 | DPP4 (0.46) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL13962959 | 0.77 | DPP4 (0.46) | ADRA2AADRA2CLMNAHIF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326834-B1 | 2-SUBSTITUTED HETEROCYCLIC COMPOUNDS | H LEE MOFFITT CANCER CT & RES (US) | 2011-06-29 | — | — | EP | disclosed |