Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 3/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501411 | 0.83 | METAP2 (0.38) | MPIPHOSPHO1ALDH1A1LMNAKDM4E | |
| SCHEMBL5916688 | 0.83 | MPI (0.58) | SMN1; SMN2MPIPHOSPHO1ALDH1A1LMNA | |
| SCHEMBL10501920 | 0.81 | METAP2 (0.40) | MPIPHOSPHO1ALDH1A1LMNAKDM4E | |
| SCHEMBL10502474 | 0.80 | ALDH1A1 (0.38) | SMN1; SMN2MPIPHOSPHO1ALDH1A1LMNA | |
| SCHEMBL10502337 | 0.79 | ALDH1A1 (0.38) | SMN1; SMN2MPIPHOSPHO1ALDH1A1LMNA | |
| SCHEMBL10501746 | 0.78 | METAP2 (0.43) | SMN1; SMN2MPIPHOSPHO1ALDH1A1LMNA | |
| SCHEMBL10746688 | 0.77 | KDM4E (0.35) | MPIPHOSPHO1ALDH1A1LMNAKDM4E | |
| SCHEMBL10748639 | 0.75 | METAP2 (0.37) | MPIPHOSPHO1ALDH1A1LMNAKDM4E | |
| SCHEMBL10744770 | 0.75 | KDM4E (0.44) | MPIPHOSPHO1ALDH1A1LMNAKDM4E | |
| SCHEMBL10502481 | 0.75 | METAP2 (0.46) | MPIPHOSPHO1ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |