Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 5/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 2/20 | 0.40 |
| ▸ | PHOSPHO1 | Q8TCT1 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916706 | 0.82 | METAP2 (0.61) | METAP2MPIPHOSPHO1TP53PKM | |
| SCHEMBL10501733 | 0.82 | METAP2 (0.36) | METAP2MPIPHOSPHO1TP53PKM | |
| SCHEMBL10502474 | 0.78 | ALDH1A1 (0.38) | METAP2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL10501684 | 0.78 | SMN1; SMN2 (0.45) | METAP2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL10501715 | 0.77 | MEN1 (0.46) | ALDH1A1KMT2AKDM4EMEN1LMNA | |
| SCHEMBL10501920 | 0.77 | METAP2 (0.40) | METAP2MPIPHOSPHO1TP53PKM | |
| SCHEMBL10501877 | 0.76 | METAP2 (0.66) | METAP2MPIPHOSPHO1TP53PKM | |
| SCHEMBL10502063 | 0.76 | METAP2 (0.39) | METAP2GRIN2BMPIPHOSPHO1TP53 | |
| SCHEMBL10746688 | 0.75 | KDM4E (0.35) | METAP2MPIPHOSPHO1TP53PKM | |
| SCHEMBL10502337 | 0.74 | ALDH1A1 (0.38) | METAP2MPIPHOSPHO1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |