Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.66 |
| ▸ | RGS12 | O14924 | 1/20 | 0.66 |
| ▸ | PMM2 | O15305 | 1/20 | 0.66 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | CYBB | P04839 | 1/20 | 0.66 |
| ▸ | BCHE | P06276 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501872 | 0.84 | METAP2 (0.62) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| SCHEMBL10503512 | 0.84 | ALDH1A1 (0.44) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| SCHEMBL10502469 | 0.84 | METAP2 (0.59) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| SCHEMBL193047 | 0.80 | METAP2 (0.79) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| Ebselen SCHEMBL4406056 | 0.80 | METAP2 (1.00) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| Ebselen SCHEMBL29370082 | 0.80 | METAP2 (1.00) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| Ebselen SCHEMBL33829 | 0.80 | METAP2 (1.00) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| SCHEMBL5916976 | 0.79 | MEN1 (0.47) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| SCHEMBL28783439 | 0.79 | METAP2 (0.77) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| Ebselen SCHEMBL19064566 | 0.79 | METAP2 (0.96) | METAP2HDAC6KDM4EMEN1QSOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| EP-0198277-B1 | DISELENO-BIS-BENZAMIDES OF PRIMARY AND SECONDARY AMINES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1989-05-03 | — | — | EP | disclosed |
| EP-0165534-B1 | S-(CARBAMOYL-PHENYLSELENYL) DERIVATIVES OF GLUTATHION AND OF AMINO MERCAPTOCARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1989-03-15 | — | — | EP | disclosed |
| EP-0187233-B1 | S-(CARBAMOYL-PHENYLSELENYL) DERIVATIVES OF MERCAPTANS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| US-4730053-A | DISEASES, CELL INJURIES, METABOLITES | A. NATTERMANN & CIE GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0198277-A1 | Diseleno-bis-benzamides of primary and secondary amines, processes for their production and pharmaceutical preparations containing them | A. Nattermann & Cie. GmbH (DE) | 1986-10-22 | — | — | EP | disclosed |
| US-4618669-A | FOR CELL INJURIES CAUSED BY ACTIVE OXYGEN METABOLITES | A. NATTERMANN & CIE GMBH (DE) | 1986-10-21 | — | — | US | disclosed |
| EP-0187233-A1 | S-(carbamoyl-phenylselenyl) derivatives of mercaptans, process for their preparation and pharmaceutical preparations containing them | A. Nattermann & Cie. GmbH (DE) | 1986-07-16 | — | — | EP | disclosed |
| EP-0165534-A2 | S-(carbamoyl-phenylselenyl) derivatives of glutathion and of amino mercaptocarboxylic acids, process for their preparation and pharmaceutical preparations containing them | A. Nattermann & Cie. GmbH (DE) | 1985-12-27 | — | — | EP | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |