Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501858 | 0.86 | KDM4E (0.40) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL10748282 | 0.81 | METAP2 (0.46) | KDM4EALDH1A1HSD17B10POLBNPC1 | |
| SCHEMBL5916620 | 0.80 | MEN1 (0.42) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL10501696 | 0.78 | METAP2 (0.46) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL10503581 | 0.75 | METAP2 (0.53) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL5916638 | 0.74 | METAP2 (0.54) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL10502494 | 0.72 | TXNRD1 (0.52) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL5916699 | 0.72 | METAP2 (0.46) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL10502365 | 0.71 | NPC1 (0.35) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL10749380 | 0.68 | METAP2 (0.42) | KDM4EALDH1A1HPGDPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |