Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.52 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.52 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.52 |
| ▸ | METAP2 | P50579 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | MMP10 | P09238 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916699 | 0.90 | METAP2 (0.46) | TXNRD1TXNRD3TXNRD2METAP2MEN1 | |
| SCHEMBL10501833 | 0.86 | NPC1 (0.43) | TXNRD1TXNRD3TXNRD2METAP2MEN1 | |
| SCHEMBL5916810 | 0.80 | METAP2 (0.40) | METAP2MEN1KMT2AKAT2BKDM4E | |
| SCHEMBL10745708 | 0.80 | TXNRD1 (0.56) | TXNRD1TXNRD3TXNRD2METAP2KMT2A | |
| SCHEMBL10501622 | 0.79 | RAB9A (0.43) | METAP2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL10501793 | 0.77 | TXNRD1 (0.52) | TXNRD1TXNRD3TXNRD2METAP2KAT2B | |
| SCHEMBL5916638 | 0.76 | METAP2 (0.54) | METAP2MEN1KMT2AKAT2BKDM4E | |
| SCHEMBL5916501 | 0.76 | L3MBTL1 (0.40) | MEN1KMT2ANPC1KAT2BKDM4E | |
| SCHEMBL10501657 | 0.75 | METAP2 (0.71) | TXNRD1TXNRD3TXNRD2METAP2MEN1 | |
| SCHEMBL5916643 | 0.75 | MPI (0.44) | METAP2MEN1KMT2AKAT2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |