Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11001264 | 0.92 | CYP2C9 (0.49) | TSHRPOLBTBXA2RADRA1ASLC6A3 | |
| SCHEMBL10502213 | 0.88 | GAA (0.40) | TSHRPOLBCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL11035332 | 0.87 | DHFR (0.44) | TSHRPOLBCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL10789096 | 0.86 | TSHR (0.58) | TSHRPOLBTBXA2RADRA1ASLC6A3 | |
| SCHEMBL10503699 | 0.85 | CACNA1F (0.41) | CACNA1CCACNA1FCACNA1DCACNA1STP53 | |
| SCHEMBL10746130 | 0.85 | ACHE (0.43) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL10503110 | 0.84 | CACNA1D (0.46) | TSHRPOLBADRA1ADRD1OPRM1 | |
| SCHEMBL10502872 | 0.82 | KDM4E (0.45) | TSHRPOLBTBXA2RADRA1ASLC6A3 | |
| SCHEMBL10502956 | 0.82 | KDM4E (0.51) | CYP2C9CYP2C19LMNAALDH1A1KDM4E | |
| SCHEMBL10502291 | 0.81 | TSHR (0.37) | TSHRTBXA2RADRA1ASLC6A3ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0133530-B1 | 1,6-NAPHTHYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICAMENTS CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1989-03-15 | — | — | EP | disclosed |
| EP-0133530-A2 | 1,6-Naphthyridinone derivatives, process for their preparation, and medicaments containing them | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1985-02-27 | — | — | EP | disclosed |