Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | SCN1A | P35498 | 2/20 | 0.45 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10503702 | 0.91 | CYP2D6 (0.49) | CYP2D6ADRB2ADRB1SIGMAR1ADRB3 | |
| SCHEMBL10594588 | 0.81 | CYP2D6 (0.45) | CYP2D6ADRB2ADRB1ADRB3CYP1A2 | |
| SCHEMBL10592061 | 0.81 | CASR (0.50) | ADRB2ADRB1ADRB3CYP1A2ALDH1A1 | |
| SCHEMBL10504761 | 0.81 | L3MBTL1 (0.47) | ADRB2ADRB1ADRB3ALDH1A1SMN1; SMN2 | |
| SCHEMBL10505401 | 0.80 | ADRB2 (0.40) | ADRB2ADRB1ADRB3CYP1A2LMNA | |
| SCHEMBL10594410 | 0.79 | ADRB2 (0.42) | ADRB2ADRB1ADRB3CYP1A2 | |
| SCHEMBL10505383 | 0.79 | ADRB2 (0.42) | ADRB2ADRB1ADRB3 | |
| SCHEMBL10592973 | 0.79 | CASR (0.49) | ADRB2ADRB1ADRB3CYP1A2SMN1; SMN2 | |
| SCHEMBL10504268 | 0.79 | ADRB2 (0.44) | CYP2D6ADRB2ADRB1ADRB3CYP1A2 | |
| SCHEMBL10592902 | 0.79 | ADRB2 (0.37) | CYP2D6ADRB2ADRB1ADRB3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200915-B1 | AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1989-09-27 | — | — | EP | disclosed |
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |