Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 9/20 | 0.54 |
| ▸ | CDC25A | P30304 | 7/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | S100A4 | P26447 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 4/20 | 0.47 |
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.46 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941466 | 0.85 | CDC25B (0.68) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL571026 | 0.85 | CDC25B (0.68) | CDC25BCDC25AAURKAAURKBS100A4 | |
| Water SCHEMBL8664586 | 0.83 | CDC25B (0.65) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL11573761 | 0.81 | S100A4 (0.50) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL15491792 | 0.80 | CDC25B (0.62) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL1197982 | 0.78 | MEN1 (0.71) | CDC25BCDC25AS100A4MEN1KMT2A | |
| SCHEMBL31129793 | 0.77 | CDC25B (0.40) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL17969766 | 0.76 | CDC25B (0.58) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL10502720 | 0.74 | S100A4 (0.55) | S100A4MAOAAPAF1CES1MAOB | |
| SCHEMBL8586117 | 0.73 | S100A4 (0.60) | CDC25BCDC25AAURKAAURKBS100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0146145-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1989-08-30 | — | — | EP | disclosed |
| US-4593120-A | Naphthalene-1,4-dicarboxylic acid group | SYNTEX (U.S.A.) INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0107512-B1 | 1,4-ACYLOXYNAPHTHALENE DERIVATIVES, TOPICAL COMPOSITIONS CONTAINING THEM, METHODS FOR THEIR PREPARATION, AND INTERMEDIATES THEREFOR | SYNTEX (U.S.A.) INC. (US) | 1986-02-26 | — | — | EP | disclosed |
| EP-0146145-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-06-26 | — | — | EP | disclosed |
| US-4466981-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1984-08-21 | — | — | US | disclosed |
| EP-0107512-A1 | 1,4-Acyloxynaphthalene derivatives, topical compositions containing them, methods for their preparation, and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1984-05-02 | — | — | EP | disclosed |