Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 8/20 | 0.60 |
| ▸ | CDC25A | P30304 | 7/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | S100A4 | P26447 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.52 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20046946 | 0.87 | IDO1 (0.58) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL9695242 | 0.86 | MAPT (0.61) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL571026 | 0.86 | CDC25B (0.68) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL29941466 | 0.86 | CDC25B (0.68) | CDC25BCDC25AAURKAAURKBS100A4 | |
| Water SCHEMBL8664586 | 0.83 | CDC25B (0.65) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL17969766 | 0.82 | CDC25B (0.58) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL5138652 | 0.81 | CDC25B (0.58) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL15491792 | 0.81 | CDC25B (0.62) | CDC25BCDC25AAURKAAURKBS100A4 | |
| SCHEMBL14003716 | 0.80 | CDC25B (0.73) | CDC25BCDC25AS100A4MEN1KMT2A | |
| SCHEMBL29424584 | 0.80 | BACE1 (0.56) | CDC25BCDC25AAURKAAURKBS100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044375-A2 | APOGOSSYPOLONE DERIVATIVES AS ANTICANCER AGENTS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-04-14 | — | — | WO | disclosed |