Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.46 |
| ▸ | DRD2 | P14416 | 11/20 | 0.46 |
| ▸ | HTR7 | P34969 | 11/20 | 0.46 |
| ▸ | HTR6 | P50406 | 11/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5407608 | 0.89 | DRD2 (0.47) | HTR2ADRD2HTR7HTR6 | |
| SCHEMBL6870309 | 0.84 | DRD2 (0.45) | HTR2ADRD2HTR7HTR6 | |
| SCHEMBL8249064 | 0.78 | DRD2 (0.47) | HTR2ADRD2HTR7HTR6HTR1A | |
| SCHEMBL7539608 | 0.76 | DRD2 (0.47) | HTR2ADRD2HTR7HTR6 | |
| SCHEMBL15266105 | 0.76 | HTR2A (0.47) | HTR2ADRD2HTR7HTR6HTR1A | |
| SCHEMBL5511869 | 0.75 | LMNA (0.51) | HTR2ADRD2HTR7HTR6 | |
| SCHEMBL11011062 | 0.73 | ACHE (0.54) | HTR2ADRD2HTR7HTR6 | |
| Hydrochloric Acid SCHEMBL10640845 | 0.72 | ACHE (0.53) | HTR2ADRD2HTR7HTR6 | |
| SCHEMBL5450472 | 0.72 | DRD2 (0.43) | HTR2ADRD2HTR7HTR6 | |
| SCHEMBL24410388 | 0.72 | DRD2 (0.47) | HTR2ADRD2HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0104632-B1 | 1'-(3-(1,2-BENZISOXAZOL-3-YL)PROPYL)SPIRO-(BENZOFURAN-2-(3H),3' OR 4'-PIPERIDINE OR 3'-PYRROLIDINES), A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-03-01 | — | — | EP | disclosed |
| EP-0104632-A2 | 1'-(3-(1,2-Benzisoxazol-3-yl)propyl)spiro-(benzofuran-2-(3H),3' or 4'-piperidine or 3'-pyrrolidines), a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-04-04 | — | — | EP | disclosed |
| US-4420485-A | HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-12-13 | — | — | US | disclosed |