SCHEMBL1050340

SCHEMBL1050340

O=C(O)c1cc(=O)n(F)c(=O)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 2/20 0.48
ALOX15 P16050 1/20 0.48
BLM P54132 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
ALDH1A1 P00352 3/20 0.44
LMNA P02545 2/20 0.44
CYP2C19 P33261 3/20 0.41
TSHR P16473 2/20 0.39
ALKBH5 Q6P6C2 6/20 0.38
KDM4E B2RXH2 3/20 0.37
HPGD P15428 3/20 0.37
HSD17B10 Q99714 3/20 0.37
GPR35 Q9HC97 3/20 0.37
MEN1 O00255 1/20 0.37
GRIN2D O15399 1/20 0.37
GRIN3B O60391 1/20 0.37
CYP1A2 P05177 1/20 0.37
GLA P06280 1/20 0.37
GAA P10253 1/20 0.37
MAPK1 P28482 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL27669910 0.98 NFKB1 (0.47) NFKB1ALOX15BLMSMN1; SMN2ALDH1A1
SCHEMBL8149936 0.77 NFKB1 (0.45) NFKB1ALOX15BLMSMN1; SMN2ALDH1A1
SCHEMBL3793592 0.76 SMN1; SMN2 (0.48) NFKB1ALOX15BLMSMN1; SMN2ALDH1A1
SCHEMBL20791866 0.76 ALOX15 (0.48) NFKB1ALOX15BLMSMN1; SMN2ALDH1A1
SCHEMBL8208517 0.76 ALOX15 (0.48) NFKB1ALOX15BLMSMN1; SMN2ALDH1A1
SCHEMBL29216005 0.76 BLM (0.48) NFKB1ALOX15BLMSMN1; SMN2ALDH1A1
SCHEMBL9715396 0.76 NFKB1 (0.44) NFKB1ALOX15BLMSMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL11439571 0.74 SMN1; SMN2 (0.47) NFKB1ALOX15BLMSMN1; SMN2ALDH1A1
SCHEMBL7403411 0.73 ALOX15 (0.45) NFKB1ALOX15BLMSMN1; SMN2ALDH1A1
SCHEMBL13401695 0.71 SMN1; SMN2 (0.42) NFKB1ALOX15BLMSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2896686-A1 Talaromyces strains and enzyme compositions DSM IP Assets B.V. (NL) 2015-07-22 EP disclosed
CN-102197047-B Mutant delta 5 desaturases and their use in making polyunsaturated fatty acids DU PONT 2014-07-09 CN disclosed
US-8461320-B2 Metabolism mutant; nucleic acid cassette DUPONT NUTRITION BIOSCIENCES APS (DK) 2013-06-11 US disclosed
US-8377681-B2 Evolution of whole cells and organisms by recursive sequence recombination CODEXIS MAYFLOWER HOLDINGS, LLC (US) 2013-02-19 US disclosed
WO-2013003545-A1 TUNING OF FUSEL ALCOHOL BY-PRODUCTS DURING ISOBUTANOL PRODUCTION BY RECOMBINANT MICROORGANISMS GEVO, INC. (US) 2013-01-03 WO disclosed
CN-101909581-B Sterol-modified amphiphilic lipids UNIV CALIFORNIA 2012-11-14 CN disclosed
US-20120252681-A1 EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION CODEXIS MAYFLOWER HOLDINGS, LLC (US) 2012-10-04 US disclosed
US-20120114797-A1 TALAROMYCES STRAINS AND ENZYME COMPOSITIONS DSM IP ASSETS B.V. (NL) 2012-05-10 US disclosed
EP-2449087-A1 TALAROMYCES STRAINS AND ENZYME COMPOSITIONS DSM IP Assets B.V. (NL) 2012-05-09 EP disclosed
US-8076138-B2 Evolution of whole cells and organisms by recursive sequence recombination CODEXIS MAYFLOWER HOLDINGS, LLC (US) 2011-12-13 US disclosed
US-5854039-A Transformation of pichia methanolica ZYMOGENETICS, INC. (US) 1998-12-29 US disclosed
EP-0862640-A2 PRODUCTION OF GAD65 IN METHYLOTROPHIC YEAST ZymoGenetics, Inc. (US) 1998-09-09 EP disclosed
EP-0833922-A1 A NOVEL METHOD TO ISOLATE MUTANTS AND TO CLONE THE COMPLEMENTING GENE DANISCO INGREDIENTS A/S (DANISCO A/S) (DK) 1998-04-08 EP disclosed
US-5736383-A EXPOSING YEAST CELLS TO MUTAGENIZING CONDITIONS AND CULTURING IN A NITROGEN DEFICIENT MEDIUM CONTAINING NYSTATIN FOR SELECTIVE KILLING OF CELLS WHICH ARE NOT AUXOTROPIC FOR ADENINE ZYMOGENETICS, INC. (US) 1998-04-07 US disclosed
US-5716808-A Genetic engineering of pichia methanolica ZYMOGENETICS, INC. (US) 1998-02-10 US disclosed
WO-1998002565-A1 TRANSFORMATION OF $i(PICHIA METHANOLICA) ZYMOGENETICS, INC. (US) 1998-01-22 WO disclosed
WO-1998002536-A2 PREPARATION OF PICHIA METHANOLICA AUXOTROPHIC MUTANTS ZYMOGENETICS, INC. (US) 1998-01-22 WO disclosed
WO-1997017450-A2 COMPOSITIONS AND METHODS FOR PRODUCING HETEROLOGOUS POLYPEPTIDES IN PICHIA METHANOLICA ZYMOGENETICS, INC. (US) 1997-05-15 WO disclosed
WO-1997017451-A2 PRODUCTION OF GAD65 IN METHYLOTROPHIC YEAST ZYMOGENETICS, INC. (US) 1997-05-15 WO disclosed
WO-1997000962-A1 A NOVEL METHOD TO ISOLATE MUTANTS AND TO CLONE THE COMPLEMENTING GENE DANISCO INGREDIENTS A/S (DANISCO A/S) (DK) 1997-01-09 WO disclosed