Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9461919 | 0.78 | MC4R (0.53) | HPGDTSHRMC4RPDE4APDE4B | |
| SCHEMBL8188156 | 0.76 | MC4R (0.66) | MC4RTACR1TP53SMN1; SMN2NPC1 | |
| SCHEMBL18187683 | 0.75 | MGLL (0.64) | — | |
| SCHEMBL16080214 | 0.74 | HPGD (0.64) | HPGDTSHRPDE4APDE4BPDE4C | |
| SCHEMBL434087 | 0.74 | HPGD (0.64) | HPGDTSHRPDE4APDE4BPDE4C | |
| SCHEMBL9633705 | 0.74 | MC4R (0.46) | HPGDTSHRMC4RTACR1MAPT | |
| SCHEMBL13443303 | 0.72 | MC4R (0.60) | TSHRMC4RMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3956954 | 0.72 | MC4R (0.69) | TSHRMC4RMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL13036597 | 0.72 | HPGD (0.60) | HPGDTSHRPDE4APDE4BPDE4C | |
| SCHEMBL4922166 | 0.71 | HPGD (0.64) | HPGDTSHRPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0136658-B1 | -1-BENZYL-AMINOALKYL-PYRROLIDINONES AND THEIR ADDITION SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | BOEHRINGER INGELHEIM KG (DE) | 1989-04-26 | — | — | EP | disclosed |
| EP-0136658-A2 | -1-Benzyl-aminoalkyl-pyrrolidinones and their addition salts, process for their preparation and pharmaceutical compounds containing them | BOEHRINGER INGELHEIM KG (DE) | 1985-04-10 | — | — | EP | disclosed |