Sugi Predict

Sugi Predict / Compounds / SCHEMBL4922166

SCHEMBL4922166

SCHEMBL4922166

O=C1C[C@H](O)CN1Cc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 1/20 0.64
▸ TSHR P16473 1/20 0.64
▸ DPP4 P27487 2/20 0.52
▸ SMN1; SMN2 Q16637 3/20 0.51
▸ ALDH1A1 P00352 3/20 0.51
▸ HTT P42858 1/20 0.50
▸ NPC1 O15118 1/20 0.49
▸ LMNA P02545 1/20 0.49
▸ GLA P06280 1/20 0.49
▸ MAPT P10636 1/20 0.49
▸ RAB9A P51151 1/20 0.49
▸ PDE4A P27815 1/20 0.49
▸ PDE4B Q07343 1/20 0.49
▸ PDE4C Q08493 1/20 0.49
▸ PDE4D Q08499 1/20 0.49
▸ APEX1 P27695 1/20 0.49
▸ BLM P54132 1/20 0.49
▸ KMT2A Q03164 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31190825 1.00 HPGD (0.64) HPGDTSHRDPP4SMN1; SMN2ALDH1A1
SCHEMBL4925533 1.00 HPGD (0.64) HPGDTSHRDPP4SMN1; SMN2ALDH1A1
SCHEMBL4922178 1.00 HPGD (0.64) HPGDTSHRDPP4SMN1; SMN2ALDH1A1
SCHEMBL6162353 0.94 HPGD (0.57) HPGDTSHRDPP4SMN1; SMN2ALDH1A1
SCHEMBL6162246 0.94 HPGD (0.57) HPGDTSHRDPP4SMN1; SMN2ALDH1A1
SCHEMBL6442016 0.87 HPGD (0.51) HPGDTSHRDPP4SMN1; SMN2ALDH1A1
SCHEMBL6159065 0.87 HPGD (0.50) HPGDTSHRDPP4SMN1; SMN2HTT
SCHEMBL6161961 0.87 HPGD (0.50) HPGDTSHRSMN1; SMN2ALDH1A1HTT
SCHEMBL6158312 0.87 HPGD (0.50) HPGDTSHRDPP4SMN1; SMN2ALDH1A1
SCHEMBL6157539 0.87 HPGD (0.50) HPGDTSHRDPP4SMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110724084-B Synthesis method of (S) -3-hydroxy-1-benzylpyrrolidine 苏州永健生物医药有限公司 2022-03-04 — — CN claimed
CN-110724084-A Synthesis method of (S) -3-hydroxy-1-benzylpyrrolidine 苏州永健生物医药有限公司 2020-01-24 — — CN claimed
CN-109929327-A Inorganic nano material prints ink and its preparation method and application TCL集团股份有限公司 2019-06-25 — — CN claimed
CN-110724084-B Synthesis method of (S) -3-hydroxy-1-benzylpyrrolidine 苏州永健生物医药有限公司 2022-03-04 — — CN disclosed
CN-110724084-B Synthesis method of (S) -3-hydroxy-1-benzylpyrrolidine 苏州永健生物医药有限公司 2022-03-04 — — CN disclosed
CN-110724084-A Synthesis method of (S) -3-hydroxy-1-benzylpyrrolidine 苏州永健生物医药有限公司 2020-01-24 — — CN disclosed
CN-110724084-A Synthesis method of (S) -3-hydroxy-1-benzylpyrrolidine 苏州永健生物医药有限公司 2020-01-24 — — CN disclosed
CN-109929327-A Inorganic nano material prints ink and its preparation method and application TCL集团股份有限公司 2019-06-25 — — CN disclosed
US-9725442-B2 Heterocyclic derivative having PGD2 receptor antagonist activity SHIONOGI & CO., LTD. (JP) 2017-08-08 — — US disclosed
US-7390825-B1 Process for the preparation of oxazolidinones and method of use thereof BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2008-06-24 — — US disclosed
US-20080146458-A1 PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2008-06-19 — — US disclosed
EP-1578723-A4 PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF UNIV MICHIGAN STATE (US) 2006-11-02 — — EP disclosed
EP-1325146-B1 PROCESS FOR PREPARING OPTICALLY ACTIVE 4-HYDROXY-2-PYRROLIDINONE AND N-SUBSTITUTED 4-HYDROXY-2-PYRROLIDINONES BY ENZYMATIC HYDROXYLATION EIDGENOESSICHE TECH HOCHSCHULE (CH) 2005-12-14 — — EP disclosed
EP-1578723-A3 PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF MICHIGAN STATE UNIVERSITY (US) 2005-10-20 — — EP disclosed
EP-1578723-A2 PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF MICHIGAN STATE UNIVERSITY (US) 2005-09-28 — — EP disclosed
US-20040009562-A1 Process for preparing optically active 4-hydroxy-2-pyrrolidinone and n-substituted 4-hydroxy-2-pyrrolidinones by enzymatic hydroxylation EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH (CH) 2004-01-15 — — US disclosed
WO-2003106413-A2 PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF MICHIGAN STATE UNIVERSITY (US) 2003-12-24 — — WO disclosed
EP-1325146-A2 PROCESS FOR PREPARING OPTICALLY ACTIVE 4-HYDROXY-2-PYRROLIDINONE AND N-SUBSTITUTED 4-HYDROXY-2-PYRROLIDINONES BY ENZYMATIC HYDROXYLATION Eidgenössiche Technische Hochschule Zürich (CH) 2003-07-09 — — EP disclosed
WO-2002031174-A2 PROCESS FOR PREPARING OPTICALLY ACTIVE 4-HYDROXY-2-PYRROLIDINONE AND N-SUBSTITUTED 4-HYDROXY-2-PYRROLIDINONES BY ENZYMATIC HYDROXYLATION EIDGENÖSSICHE TECHNISCHE HOCHSCHULE ZÜRICH (CH) 2002-04-18 — — WO disclosed
EP-1197561-A1 Process for preparing optically active 4-hydroxy-2-pyrrolidinone and N-substituted 4-hydroxy-2-pyrrolidinones by enzymatic hydroxylation Eidgenössische Technische Hochschule Zürich (CH) 2002-04-17 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080146458-A1 PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF OXA1L, OGFOD1, CYP51A1 HPGD 977/4885TSHR 2539/4885DPP4 1011/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.