SCHEMBL10508148

SCHEMBL10508148

COc1nc(NC(=O)NS(=O)(=O)c2ccccc2C(=O)OC(C)C)nc(OC)n1

nearest known ligand 0.61

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.45
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
MAPT P10636 1/20 0.43
GAA P10253 2/20 0.41
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
CDK1 P06493 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA5A P35218 1/20 0.38
CA9 Q16790 1/20 0.38
SLC40A1 Q9NP59 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10506658 0.94 NPC1 (0.42) NPC1KDM4EALDH1A1MAPTGAA
SCHEMBL7023958 0.90 NPC1 (0.50) NPC1KDM4EALDH1A1MAPTGAA
SCHEMBL10759233 0.86 NPC1 (0.40) NPC1KDM4EALDH1A1MAPTGAA
SCHEMBL11177162 0.86 NPC1 (0.43) NPC1KDM4EALDH1A1MAPTGAA
SCHEMBL7452390 0.85 MAPT (0.49) NPC1KDM4EALDH1A1MAPTGAA
SCHEMBL11184973 0.85 ALDH1A1 (0.52) NPC1KDM4EALDH1A1MAPTKMT2A
SCHEMBL11189126 0.85 NPC1 (0.42) NPC1KDM4EALDH1A1MAPTGAA
SCHEMBL10758377 0.85 GAA (0.47) NPC1KDM4EALDH1A1MAPTGAA
Metsulfuron-Methyl SCHEMBL21583 0.83 NPC1 (0.46) NPC1KDM4EALDH1A1MAPTGAA
Metsulfuron-Methyl SCHEMBL9136999 0.83 NPC1 (0.46) NPC1KDM4EALDH1A1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4383113-A PLANT GROWTH REGULATORS, HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1983-05-10 US claimed
EP-0007687-B1 SULFONAMIDES, PROCESSES FOR THEIR PREPARATION, COMPOSITIONS CONTAINING SAID SULFONAMIDES AND A METHOD FOR CONTROLLING THE GROWTH OF VEGETATION E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-03-30 EP claimed
EP-0007687-A1 Sulfonamides, processes for their preparation, compositions containing said sulfonamides and a method for controlling the growth of vegetation E.I. DU PONT DE NEMOURS AND COMPANY (US) 1980-02-06 EP claimed
US-4830662-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-05-16 US disclosed
US-4818278-A N-/HETEROCYCLICAMINOCARBONYL/ARYL SULFONAMIDES; HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-04-04 US disclosed
US-4755216-A Herbicides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-07-05 US disclosed
US-4721520-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-01-26 US disclosed
US-4689072-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-08-25 US disclosed
US-4687507-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-08-18 US disclosed
US-4647303-A Agriculture sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-03-03 US disclosed
US-4627873-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1986-12-09 US disclosed
US-4545808-A PREEMERGENCE AND POSTEMERGENCE HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-10-08 US disclosed
US-4536576-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-08-20 US disclosed
US-4394506-A HERBICIDWS, PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1983-07-19 US disclosed
US-4383113-A PLANT GROWTH REGULATORS, HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1983-05-10 US disclosed
EP-0007687-B1 SULFONAMIDES, PROCESSES FOR THEIR PREPARATION, COMPOSITIONS CONTAINING SAID SULFONAMIDES AND A METHOD FOR CONTROLLING THE GROWTH OF VEGETATION E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-03-30 EP disclosed
US-4305884-A 0-CARBONYLBENZENESULFONYL ISOCYANATES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-12-15 US disclosed
EP-0034431-A2 2-Isocyanatosulfonylbenzoic acid esters and preparation thereof E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-08-26 EP disclosed
US-4238621-A CARBONYLBENZENESULFONYL ISOCYANATES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1980-12-09 US disclosed
EP-0007687-A1 Sulfonamides, processes for their preparation, compositions containing said sulfonamides and a method for controlling the growth of vegetation E.I. DU PONT DE NEMOURS AND COMPANY (US) 1980-02-06 EP disclosed