Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | GALK1 | P51570 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | USP18 | Q9UMW8 | 1/20 | 0.40 |
| ▸ | UCHL5 | Q9Y5K5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10509375 | 1.00 | CYP19A1 (0.51) | CYP19A1PTGS2PTGS1MAPTNPC1 | |
| SCHEMBL22911974 | 0.84 | ALDH1A1 (0.51) | MAPTRAB9AMEN1KMT2ABCHE | |
| SCHEMBL11022300 | 0.84 | MAOB (0.40) | CYP19A1PTGS2PTGS1MAPTMEN1 | |
| SCHEMBL11022298 | 0.84 | MAOB (0.40) | CYP19A1PTGS2PTGS1MAPTMEN1 | |
| SCHEMBL10506622 | 0.83 | MAOA (0.48) | MEN1KMT2AMAOBALDH1A1 | |
| SCHEMBL10506627 | 0.83 | MAOA (0.48) | MEN1KMT2AMAOBALDH1A1 | |
| SCHEMBL10507593 | 0.78 | MEN1 (0.48) | MAPTMEN1KMT2AFBP1MAOB | |
| SCHEMBL10507599 | 0.78 | MEN1 (0.48) | MAPTMEN1KMT2AFBP1MAOB | |
| SCHEMBL10507533 | 0.77 | RELA (0.48) | CYP19A1PTGS2PTGS1MAPTAPP | |
| SCHEMBL2532509 | 0.76 | ALDH1A1 (0.51) | MAPTMEN1KMT2ABCHEMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164593-B1 | ANTI-INFLAMMATORY PHTHALAZINONES | FISONS CORPORATION (US) | 1989-11-15 | — | — | EP | disclosed |
| US-4665181-A | Anti-inflammatory phthalazinones | PENNWALT CORPORATION (US) | 1987-05-12 | — | — | US | disclosed |
| EP-0164593-A1 | Anti-inflammatory phthalazinones | FISONS CORPORATION (US) | 1985-12-18 | — | — | EP | disclosed |