Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10563794 | 0.70 | HCAR3 (0.41) | HCAR3MAPK1HSD17B10 | |
| SCHEMBL10568686 | 0.69 | PDE4B (0.58) | PDE5APDE4BMEN1KMT2AMAPK1 | |
| SCHEMBL11602099 | 0.64 | PDE4B (0.65) | PDE5APDE4BMEN1KMT2A | |
| SCHEMBL987741 | 0.63 | PDE4B (0.60) | PDE5APDE4BMEN1KMT2ANR3C1 | |
| SCHEMBL11396345 | 0.63 | PDE5A (0.54) | PDE5APDE4BMEN1KMT2ANR3C1 | |
| SCHEMBL5928041 | 0.63 | PDE4B (0.76) | PDE5APDE4BMEN1KMT2AMAPK1 | |
| SCHEMBL4968650 | 0.62 | POLB (0.42) | PDE5AMEN1KMT2AMAPK1 | |
| SCHEMBL11081643 | 0.62 | HCAR3 (0.46) | HCAR3JAK2JAK1JAK3MAPK1 | |
| SCHEMBL11602092 | 0.62 | PDE4B (0.56) | PDE5APDE4BMEN1KMT2ANR3C1 | |
| SCHEMBL4816675 | 0.62 | PDE5A (0.53) | PDE5APDE4BMEN1KMT2ANR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0152910-B1 | PYRAZOLOPYRIDINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1989-07-12 | — | — | EP | disclosed |
| EP-0152910-A2 | pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-08-28 | — | — | EP | disclosed |