Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10567519 | 0.88 | JAK3 (0.38) | HCAR3 | |
| SCHEMBL10567101 | 0.88 | HPGD (0.37) | HCAR3 | |
| SCHEMBL10509852 | 0.83 | MEN1 (0.44) | MAPK1HSD17B10KDM4EALDH1A1RAB9A | |
| SCHEMBL10568325 | 0.78 | MEN1 (0.32) | HCAR3MAPK1HSD17B10KDM4EALDH1A1 | |
| SCHEMBL10565713 | 0.78 | KDM6B (0.44) | HCAR3KDM4EALDH1A1RAB9A | |
| SCHEMBL10566676 | 0.75 | HPGD (0.33) | HTR2A | |
| SCHEMBL13544631 | 0.70 | KDM6B (0.33) | KDM4EALDH1A1 | |
| SCHEMBL10509848 | 0.70 | HCAR3 (0.38) | HCAR3MAPK1HSD17B10 | |
| SCHEMBL10507536 | 0.68 | TGFBR1 (0.40) | HCAR3MAPK1HSD17B10KDM4EALDH1A1 | |
| SCHEMBL11081643 | 0.65 | HCAR3 (0.46) | HCAR3MAPK1HSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | claimed |
| US-4837238-A | Pharmacologically useful pyrazolopyridines | BEECHAM GROUP P.L.C. (GB) | 1989-06-06 | — | — | US | disclosed |
| EP-0193329-A2 | Pyrazolopyridines, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-09-03 | — | — | EP | disclosed |