Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CD44 | P16070 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3132841 | 0.80 | CD44 (0.46) | ALDH1A1L3MBTL1CD44 | |
| SCHEMBL11780183 | 0.80 | TAAR1 (0.47) | MPOTAAR1HTTALDH1A1NPC1 | |
| SCHEMBL1750348 | 0.77 | TAAR1 (0.43) | MPOTAAR1ALDH1A1L3MBTL1IDO1 | |
| SCHEMBL31470103 | 0.74 | HTT (0.51) | TAAR1HTTNPC1L3MBTL1IDO1 | |
| SCHEMBL2356316 | 0.74 | CYP3A4 (0.41) | ALDH1A1L3MBTL1CD44AR | |
| SCHEMBL11778004 | 0.73 | ALDH1A1 (0.47) | MPOTAAR1HTTALDH1A1NPC1 | |
| SCHEMBL601969 | 0.73 | — | — | |
| SCHEMBL29803091 | 0.73 | — | — | |
| SCHEMBL5205493 | 0.72 | TAAR1 (0.46) | MPOTAAR1HTTALDH1A1NPC1 | |
| SCHEMBL28047780 | 0.72 | TAAR1 (0.47) | MPOTAAR1NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0145037-B1 | N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-18 | — | — | EP | disclosed |
| EP-0145037-A2 | N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-06-19 | — | — | EP | disclosed |