Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ATP4A | P20648 | 1/20 | 0.38 |
| ▸ | ATP4B | P51164 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL108534 | 0.78 | TDP1 (0.48) | TAAR1L3MBTL1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL10510260 | 0.77 | MPO (0.42) | TAAR1L3MBTL1LMNAALDH1A1IDO1 | |
| SCHEMBL28846076 | 0.76 | HTR1A (0.51) | TAAR1SMN1; SMN2IDO1 | |
| SCHEMBL5829892 | 0.74 | IDO1 (0.47) | TAAR1L3MBTL1TDP1ALDH1A1IDO1 | |
| SCHEMBL1161154 | 0.74 | TAAR1 (0.52) | TAAR1LMNASMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL30122828 | 0.74 | TAAR1 (0.52) | TAAR1LMNASMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL3256812 | 0.73 | ALDH1A1 (0.41) | L3MBTL1LMNATDP1ALDH1A1KMT2A | |
| SCHEMBL1353991 | 0.73 | IDO1 (0.48) | TAAR1LMNASMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL2426746 | 0.73 | CD274 (0.49) | TAAR1L3MBTL1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL17058000 | 0.73 | IDO1 (0.46) | TAAR1LMNASMN1; SMN2TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968534-B2 | Sulfonamide derivatives, preparation thereof and use thereof as antagonists of orexin 2 receptors | SANOFI-AVENTIS (FR) | 2011-06-28 | — | — | US | disclosed |
| US-20090042851-A1 | SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF AS ANTAGONISTS OF OREXIN 2 RECEPTORS | SANOFI-AVENTIS (FR) | 2009-02-12 | — | — | US | disclosed |
| EP-1981873-A1 | SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085718-A1 | SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042851-A1 | SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF AS ANTAGONISTS OF OREXIN 2 RECEPTORS | HCRTR2, HCRTR1, NPY2R | TAAR1 48/4885L3MBTL1 4824/4885LMNA 3840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.