Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 4/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PTPRG | P23470 | 4/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9334871 | 0.87 | BCAT2 (0.48) | BCAT2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL9825602 | 0.80 | ICAM1 (0.49) | ALDH1A1MAPTMAPK8MAPK10IKBKB | |
| SCHEMBL7534963 | 0.74 | HPGD (0.44) | ALDH1A1MAPTKMT2AMEN1IKBKB | |
| SCHEMBL7270647 | 0.74 | PTPRC (0.37) | ALDH1A1MAPTKMT2AMEN1MAPK1 | |
| SCHEMBL2889862 | 0.73 | MAPT (0.61) | BCAT2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL56103 | 0.73 | — | — | |
| SCHEMBL1366984 | 0.73 | — | — | |
| SCHEMBL7073463 | 0.72 | MAPT (0.38) | ALDH1A1MAPTKMT2APTPRCPTPRG | |
| SCHEMBL11900173 | 0.71 | PTPRC (0.56) | ALDH1A1MAPTKMT2AMEN1PTPRC | |
| SCHEMBL2225907 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318682-A2 | Tricyclic thiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-07 | — | — | EP | disclosed |