Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | RAD52 | P43351 | 3/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NCF1 | P14598 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10513493 | 0.88 | KDM4E (0.52) | POLBRAD52SMARCA2KDM4EHSP90AA1 | |
| SCHEMBL10513547 | 0.88 | MAT2A (0.48) | POLBKDM4EHSP90AA1MAPK1MCL1 | |
| SCHEMBL10512619 | 0.81 | MAT2A (0.48) | POLBKDM4EHSP90AA1MAPK1MCL1 | |
| SCHEMBL10512791 | 0.78 | HPGD (0.54) | POLBKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL10513726 | 0.73 | KDM4E (0.54) | POLBKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL12072917 | 0.71 | ALDH1A1 (0.55) | POLBKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL21208490 | 0.70 | KMT2A (0.48) | POLBRAD52SMARCA2KDM4EHSP90AA1 | |
| SCHEMBL12072919 | 0.70 | KDM4E (0.52) | POLBKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL28064492 | 0.69 | HDAC1 (0.66) | POLBKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL10513759 | 0.68 | MAPT (0.51) | POLBKDM4EKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331093-A1 | Benzimidazo[1,2-c]quinazolines, their preparation and use | KNOLL AG (DE) | 1989-09-06 | — | — | EP | disclosed |