Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 16/20 | 0.68 |
| ▸ | IKBKE | Q14164 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10516944 | 0.93 | TBK1 (0.74) | TBK1IKBKERAB9ANPC1RXFP1 | |
| SCHEMBL19182071 | 0.86 | TBK1 (0.65) | TBK1IKBKERAB9ANPC1RXFP1 | |
| SCHEMBL19180639 | 0.86 | TBK1 (0.84) | TBK1IKBKERAB9ANPC1RXFP1 | |
| SCHEMBL11104770 | 0.85 | RAB9A (0.59) | TBK1IKBKERAB9ANPC1RXFP1 | |
| SCHEMBL10510862 | 0.85 | TBK1 (0.85) | TBK1IKBKERAB9ANPC1KDM4E | |
| SCHEMBL19180469 | 0.84 | TBK1 (0.74) | TBK1IKBKERAB9ANPC1RXFP1 | |
| SCHEMBL17548698 | 0.84 | TBK1 (0.74) | TBK1IKBKERAB9ANPC1RXFP1 | |
| SCHEMBL19196856 | 0.84 | TBK1 (0.82) | TBK1IKBKERAB9ANPC1RXFP1 | |
| SCHEMBL19181489 | 0.84 | TBK1 (0.72) | TBK1IKBKERAB9ANPC1RXFP1 | |
| SCHEMBL19182322 | 0.84 | TBK1 (0.81) | TBK1IKBKERAB9ANPC1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0191568-B1 | 2-Amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid derivatives and their production | Takeda Chemical Industries, Ltd. (JP) | 1989-10-25 | — | — | EP | disclosed |
| US-4716167-A | 2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-12-29 | — | — | US | disclosed |
| EP-0191568-A1 | 2-Amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid derivatives and their production | Takeda Chemical Industries, Ltd. (JP) | 1986-08-20 | — | — | EP | disclosed |