Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 20/20 | 0.85 |
| ▸ | IKBKE | Q14164 | 11/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.70 |
| ▸ | TTR | P02766 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.70 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19197560 | 0.92 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL19197557 | 0.85 | KDM4E (0.77) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL10512142 | 0.85 | TBK1 (0.68) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL10510866 | 0.84 | TBK1 (0.61) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL19197558 | 0.83 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL19180562 | 0.82 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL29642 | 0.82 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL5058549 | 0.82 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL29441547 | 0.82 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL19196842 | 0.82 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0191568-B1 | 2-Amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid derivatives and their production | Takeda Chemical Industries, Ltd. (JP) | 1989-10-25 | — | — | EP | claimed |
| US-4716167-A | 2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-12-29 | — | — | US | claimed |
| EP-0191568-A1 | 2-Amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid derivatives and their production | Takeda Chemical Industries, Ltd. (JP) | 1986-08-20 | — | — | EP | claimed |
| EP-0191568-B1 | 2-Amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid derivatives and their production | Takeda Chemical Industries, Ltd. (JP) | 1989-10-25 | — | — | EP | disclosed |
| US-4716167-A | 2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-12-29 | — | — | US | disclosed |
| EP-0191568-A1 | 2-Amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid derivatives and their production | Takeda Chemical Industries, Ltd. (JP) | 1986-08-20 | — | — | EP | disclosed |