Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10669369 | 0.87 | DRD2 (0.57) | SIGMAR1DRD2DRD4DRD3HTR2A | |
| SCHEMBL11223325 | 0.86 | SLC6A3 (0.42) | SIGMAR1DRD2DRD4DRD3HTR2A | |
| SCHEMBL10674194 | 0.84 | DRD3 (0.45) | DRD2DRD4DRD3HTR2AHTR2C | |
| SCHEMBL10506936 | 0.83 | MEN1 (0.46) | DRD2DRD4DRD3 | |
| SCHEMBL10675284 | 0.81 | DRD4 (0.46) | DRD2DRD4DRD3HTR2AHTR2C | |
| SCHEMBL7951002 | 0.79 | DRD2 (0.41) | DRD2DRD4DRD3 | |
| SCHEMBL11136336 | 0.77 | DRD4 (0.51) | DRD2DRD4DRD3MAPK14 | |
| Hydrochloric Acid SCHEMBL11220155 | 0.76 | DRD4 (0.50) | DRD2DRD4DRD3MAPK14 | |
| SCHEMBL6621730 | 0.74 | TDP1 (0.48) | DRD4DRD3HTR2A | |
| Fumaric Acid SCHEMBL10672445 | 0.74 | MAPT (0.39) | SIGMAR1DRD2DRD4DRD3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169148-B1 | INDOLE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1989-09-13 | — | — | EP | disclosed |
| EP-0169148-A1 | Indole derivatives, their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1986-01-22 | — | — | EP | disclosed |