Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10672445 | 0.90 | MAPT (0.39) | DRD2DRD4DRD3AKT1MCHR1 | |
| Fumaric Acid SCHEMBL10672429 | 0.90 | MAPT (0.39) | DRD2DRD4DRD3AKT1MCHR1 | |
| SCHEMBL10674194 | 0.85 | DRD3 (0.45) | DRD2DRD4DRD3 | |
| SCHEMBL10675284 | 0.85 | DRD4 (0.46) | DRD2DRD4DRD3HTR6ADRB1 | |
| SCHEMBL11131906 | 0.83 | ADRB1 (0.37) | DRD2DRD4DRD3AKT1HTR6 | |
| SCHEMBL8805458 | 0.80 | SIGMAR1 (0.46) | DRD2DRD4DRD3AKT1HTR6 | |
| SCHEMBL10513468 | 0.79 | SIGMAR1 (0.48) | DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL10680291 | 0.79 | SIGMAR1 (0.45) | DRD2DRD4DRD3AKT1HTR6 | |
| Hydrochloric Acid SCHEMBL10669369 | 0.78 | DRD2 (0.57) | DRD2DRD4DRD3GAA | |
| SCHEMBL10506936 | 0.77 | MEN1 (0.46) | DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255306-B1 | PSYCHOLOGICAL DISORDERS | MACOR JOHN E (US) | 2001-07-03 | — | — | US | disclosed |
| US-4737505-A | Analgesic 4-substituted indoles | ROUSSEL UCLAF (FR) | 1988-04-12 | — | — | US | disclosed |
| EP-0169148-A1 | Indole derivatives, their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1986-01-22 | — | — | EP | disclosed |