SCHEMBL10514701

SCHEMBL10514701

COC(=O)c1c(C)nn(-c2cccc(Cl)n2)c1S

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.45
ALDH1A1 P00352 2/20 0.39
KMT2A Q03164 3/20 0.38
MEN1 O00255 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
RAB9A P51151 1/20 0.37
PDE4B Q07343 1/20 0.37
POLB P06746 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36
MAPT P10636 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
PLA2G2A P14555 2/20 0.36
GPX4 P36969 1/20 0.36
TDP1 Q9NUW8 2/20 0.36
CASP3 P42574 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10521613 0.85 HPGD (0.61) HPGDALDH1A1KMT2AMEN1L3MBTL1
SCHEMBL10514601 0.81 HPGD (0.44) HPGDALDH1A1KMT2AMEN1L3MBTL1
SCHEMBL9600693 0.81 HPGD (0.51) HPGDALDH1A1KMT2AMEN1RAB9A
SCHEMBL10515649 0.76 IRAK4 (0.42) ALDH1A1KMT2AL3MBTL1RAB9AMAPT
SCHEMBL10557382 0.75 PDE4D (0.51) HPGDALDH1A1KMT2AMEN1RAB9A
SCHEMBL10513918 0.72 KDM4E (0.45) KMT2AMEN1L3MBTL1POLBTDP1
SCHEMBL9601157 0.72 HPGD (0.50) HPGDALDH1A1KMT2AMEN1RAB9A
SCHEMBL10921671 0.70 LMNA (0.40) HPGDALDH1A1KMT2AMEN1L3MBTL1
SCHEMBL10562470 0.68 ALDH1A1 (0.56) HPGDALDH1A1KMT2AMEN1RAB9A
SCHEMBL10514991 0.68 NPC1 (0.52) HPGDALDH1A1KMT2AMEN1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4881965-A CONTROLLING WILD OATS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1989-11-21 US disclosed
EP-0318602-A1 Pyrazolesulfonamide derivative, process for its production and herbicide containing it NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1989-06-07 EP disclosed