Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10516737 | 0.93 | CYP3A4 (0.50) | TDP1SLC22A2SLC22A1PGRTHRB | |
| SCHEMBL11472302 | 0.85 | EBP (0.39) | TDP1SLC22A2SLC22A1PGRTHRB | |
| SCHEMBL11470978 | 0.81 | OPRM1 (0.48) | TDP1SLC22A2SLC22A1PGRTHRB | |
| SCHEMBL10515340 | 0.80 | TDP1 (0.39) | TDP1SLC22A2SLC22A1PGRTHRB | |
| SCHEMBL10653133 | 0.78 | CYP3A4 (0.53) | TDP1SLC22A2SLC22A1PGRTHRB | |
| SCHEMBL11469619 | 0.78 | CYP3A4 (0.34) | TDP1SLC22A2SLC22A1PGRTHRB | |
| SCHEMBL11532046 | 0.77 | CYP2D6 (0.46) | TDP1SLC22A2SLC22A1PGRTHRB | |
| SCHEMBL10516235 | 0.77 | TSHR (0.54) | TDP1SLC22A2SLC22A1PGRTHRB | |
| SCHEMBL11537649 | 0.76 | KCNH2 (0.55) | TDP1SLC22A2SLC22A1PGRTHRB | |
| SCHEMBL11480207 | 0.74 | KCNA3 (0.46) | KCNH2CYP3A4RAB9ALMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175319-B1 | HEXAHYDROINDOLIZINONES | G.D. Searle & Co. (US) | 1989-12-06 | — | — | EP | disclosed |
| EP-0175319-A1 | Hexahydroindolizinones | G.D. Searle & Co. (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4567270-A | Hexahydroindolizinones useful for treating cardiac arrhythmia, thrombotic disorders in mammals | G. D. SEARLE & CO. (US) | 1986-01-28 | — | — | US | disclosed |