Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | EBP | Q15125 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11472302 | 0.95 | EBP (0.39) | OPRM1DRD3CYP2D6DRD2DRD4 | |
| SCHEMBL11530730 | 0.92 | CYP2D6 (0.56) | OPRM1DRD3CYP2D6DRD2DRD4 | |
| SCHEMBL11532046 | 0.86 | CYP2D6 (0.46) | OPRM1DRD3CYP2D6DRD2DRD4 | |
| SCHEMBL11536775 | 0.85 | EBP (0.50) | OPRM1DRD3CYP2D6DRD2DRD4 | |
| SCHEMBL11535404 | 0.84 | CYP2D6 (0.40) | OPRM1DRD3CYP2D6DRD2DRD4 | |
| SCHEMBL11469619 | 0.84 | CYP3A4 (0.34) | OPRM1DRD3CYP2D6DRD2DRD4 | |
| SCHEMBL11479884 | 0.83 | HRH3 (0.38) | OPRM1DRD3CYP2D6DRD2DRD4 | |
| SCHEMBL11480207 | 0.82 | KCNA3 (0.46) | OPRM1CYP2D6CYP3A4KCNH2CHRM2 | |
| SCHEMBL11487964 | 0.81 | KCNA3 (0.48) | OPRM1CYP2D6CYP3A4KCNH2CHRM2 | |
| SCHEMBL10516752 | 0.81 | TDP1 (0.44) | OPRM1DRD3CYP2D6DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4217306-A | ANTIARRHYTHMIA AGENTS | G. D. SEARLE & CO. (US) | 1980-08-12 | — | — | US | disclosed |