Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10517755 | 0.89 | ALDH1A1 (0.52) | KDM4EALDH1A1MAPTATMTP53 | |
| SCHEMBL10518063 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1MAPTATMGALR3 | |
| SCHEMBL7350046 | 0.78 | ALDH1A1 (0.55) | KDM4EALDH1A1MAPTATMTP53 | |
| SCHEMBL10517430 | 0.74 | PDE3B (0.39) | KDM4EALDH1A1 | |
| SCHEMBL7342402 | 0.73 | KDM4E (0.52) | KDM4EALDH1A1MAPTATMRAB9A | |
| SCHEMBL10517749 | 0.73 | ALDH1A1 (0.52) | KDM4EALDH1A1MAPTATMRAB9A | |
| SCHEMBL7342548 | 0.73 | PDE3B (0.38) | KDM4EALDH1A1 | |
| SCHEMBL7340318 | 0.70 | PDE3B (0.40) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7349137 | 0.68 | PDE4B (0.39) | KDM4EALDH1A1 | |
| SCHEMBL9763201 | 0.68 | PIM1 (0.36) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329691-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES. | SCHERING AG (DE) | 1989-08-30 | — | — | EP | disclosed |
| WO-1988003531-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-05-19 | — | — | WO | disclosed |