Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10518063 | 0.94 | KDM4E (0.49) | ALDH1A1KDM4EMAPTATMPDE3B | |
| SCHEMBL10517749 | 0.94 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTATMPDE3B | |
| SCHEMBL7342402 | 0.89 | KDM4E (0.52) | ALDH1A1KDM4EMAPTATMPDE3B | |
| SCHEMBL7342548 | 0.82 | PDE3B (0.38) | ALDH1A1KDM4EPDE3BPDE3APDE4A | |
| SCHEMBL7344749 | 0.80 | GRIK1 (0.49) | — | |
| SCHEMBL10518068 | 0.78 | KDM4E (0.49) | ALDH1A1KDM4EMAPTATMRAB9A | |
| SCHEMBL10517755 | 0.78 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTATMRAB9A | |
| SCHEMBL7341161 | 0.76 | PDE3B (0.54) | ALDH1A1PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7340697 | 0.75 | LMNA (0.47) | ALDH1A1MAPTATMMEN1KMT2A | |
| SCHEMBL31213128 | 0.70 | ALDH1A1 (0.61) | ALDH1A1KDM4EMAPTATMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329691-B1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-11-21 | — | — | EP | disclosed |
| US-4737511-A | Cardiotonic imidazolylphenylpyrrol-2-ones | SCHERING A.G. (DE) | 1988-04-12 | — | — | US | disclosed |