Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | ADH5 | P11766 | 2/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342548 | 0.73 | PDE3B (0.38) | PDE3BPDE3AALDH1A1PIK3CAMTOR | |
| SCHEMBL7340318 | 0.72 | PDE3B (0.40) | PDE3BPDE3AALDH1A1PIK3CAMTOR | |
| SCHEMBL7349137 | 0.70 | PDE4B (0.39) | PDE3BPDE3AALDH1A1PIK3CAMTOR | |
| SCHEMBL10517430 | 0.68 | PDE3B (0.39) | PDE3BPDE3AALDH1A1KDM4EPDE4A | |
| SCHEMBL10518068 | 0.68 | KDM4E (0.49) | ALDH1A1KDM4E | |
| SCHEMBL10517424 | 0.67 | PDE3B (0.42) | PDE3BPDE3AALDH1A1KDM4EPDE4A | |
| SCHEMBL10518063 | 0.66 | KDM4E (0.49) | PDE3BPDE3AALDH1A1KDM4EPDE4A | |
| SCHEMBL10899684 | 0.65 | ALDH1A1 (0.62) | ALDH1A1KDM4ECYP2E1CYP3A4CYP2A6 | |
| SCHEMBL6258693 | 0.65 | CYP3A4 (0.47) | ALDH1A1KDM4EGAACYP2E1CYP3A4 | |
| SCHEMBL15778631 | 0.62 | CYP3A4 (0.53) | ALDH1A1PIK3CAMTORKDM4EADH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329691-B1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-11-21 | — | — | EP | disclosed |