Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 1.00 |
| ▸ | NPC1 | O15118 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 8/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | PNLIP | P16233 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | AHR | P35869 | 1/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28343753 | 0.85 | METAP2 (0.73) | METAP2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18818114 | 0.84 | RAB9A (0.73) | METAP2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL1499502 | 0.83 | KMT2A (0.75) | METAP2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10521106 | 0.83 | METAP2 (0.75) | METAP2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8356819 | 0.83 | METAP2 (0.70) | METAP2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10520399 | 0.82 | METAP2 (0.70) | METAP2NPC1RAB9AMEN1KMT2A | |
| Ebselen Diselenide SCHEMBL10520791 | 0.82 | METAP2 (1.00) | METAP2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5080078 | 0.81 | PNLIP (0.91) | METAP2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3949532 | 0.81 | KMT2A (0.78) | METAP2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10062017 | 0.81 | NPC1 (1.00) | METAP2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873350-A | Diselenobis-benzoic acid amides of primary and secondary amines and processes for the treatment of diseases in humans caused by a cell injury | A NATTERMANN & CIE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0198277-B1 | DISELENO-BIS-BENZAMIDES OF PRIMARY AND SECONDARY AMINES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1989-05-03 | — | — | EP | disclosed |
| EP-0198277-A1 | Diseleno-bis-benzamides of primary and secondary amines, processes for their production and pharmaceutical preparations containing them | A. Nattermann & Cie. GmbH (DE) | 1986-10-22 | — | — | EP | disclosed |