Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521236 | 0.85 | ALDH1A1 (0.41) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10522549 | 0.83 | MAPT (0.47) | MAPTRAB9ANPC1SMN1; SMN2ALOX5 | |
| SCHEMBL2174292 | 0.81 | AAK1 (0.36) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1643846 | 0.81 | SLC6A2 (0.39) | MAPTNPC1SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL8539792 | 0.80 | SMN1; SMN2 (0.40) | RAB9ASMN1; SMN2ALDH1A1TP53L3MBTL1 | |
| SCHEMBL3913255 | 0.79 | ALDH1A1 (0.49) | MAPTRAB9ANPC1SMN1; SMN2ALOX5 | |
| SCHEMBL15155861 | 0.79 | MAPT (0.48) | MAPTRAB9ANPC1SMN1; SMN2ALOX5 | |
| SCHEMBL29868333 | 0.79 | ALDH1A1 (0.49) | MAPTRAB9ANPC1SMN1; SMN2ALOX5 | |
| SCHEMBL4335628 | 0.79 | SLC7A5 (0.39) | SMN1; SMN2ALDH1A1L3MBTL1TSHRMAPK1 | |
| SCHEMBL4335630 | 0.79 | SLC7A5 (0.39) | SMN1; SMN2ALDH1A1L3MBTL1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4818748-A | HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1989-04-04 | — | — | US | disclosed |
| EP-0236874-A2 | Renin inhibitors, their production and use, as well as derivatives of amino acids and amino aldehydes | BAYER AG (DE) | 1987-09-16 | — | — | EP | disclosed |