SCHEMBL4335628

SCHEMBL4335628

CCc1cccc(N(C(=O)OC(C)(C)C)[C@@H](C)C=O)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.39
ALDH1A1 P00352 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
PTGS2 P35354 1/20 0.34
SIGMAR1 Q99720 6/20 0.34
NR1H4 Q96RI1 2/20 0.34
CTSK P43235 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
NCOR2 Q9Y618 1/20 0.33
AKT1 P31749 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
ITGB1 P05556 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4335630 1.00 SLC7A5 (0.39) SLC7A5ALDH1A1SMN1; SMN2PTGS2SIGMAR1
SCHEMBL1643846 0.82 SLC6A2 (0.39) ALDH1A1SMN1; SMN2CYP2C19
SCHEMBL2174292 0.82 AAK1 (0.36) ALDH1A1SMN1; SMN2CTSKTDP1L3MBTL1
SCHEMBL8539792 0.82 SMN1; SMN2 (0.40) ALDH1A1SMN1; SMN2AKT1TSHRTDP1
SCHEMBL10519366 0.79 MAPT (0.45) ALDH1A1SMN1; SMN2TSHRMAPK1L3MBTL1
SCHEMBL24449497 0.78 BRD4 (0.49) SIGMAR1
SCHEMBL7447861 0.78 MEN1 (0.40) ALDH1A1SMN1; SMN2CTSK
SCHEMBL2819915 0.77 SLC7A5 (0.40) SLC7A5ALDH1A1SMN1; SMN2NR1H4L3MBTL1
SCHEMBL7630006 0.75 ALOX5 (0.47) L3MBTL1
SCHEMBL4330644 0.75 PPARG (0.37) HDAC3HDAC1HDAC2NCOR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2102169-A1 INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS AstraZeneca AB (SE) 2009-09-23 EP disclosed
WO-2008076048-A1 INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS ASTRAZENECA AB (SE) 2008-06-26 WO disclosed