Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10519990 | 1.00 | ALDH1A1 (0.48) | ALDH1A1MAPTKDM4EHSD17B10MEN1 | |
| SCHEMBL10520041 | 0.89 | ALDH1A1 (0.48) | ALDH1A1MAPTKDM4EHSD17B10MEN1 | |
| Fumaric Acid SCHEMBL10520381 | 0.89 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4EHSD17B10MEN1 | |
| Maleic Acid SCHEMBL10520379 | 0.89 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4EHSD17B10MEN1 | |
| SCHEMBL10518389 | 0.78 | SMN1; SMN2 (0.61) | ALDH1A1MAPTKDM4EHSD17B10MEN1 | |
| SCHEMBL10517171 | 0.77 | HSD17B10 (0.46) | ALDH1A1MAPTKDM4EHSD17B10MEN1 | |
| Fumaric Acid SCHEMBL10517651 | 0.76 | ALDH1A1 (0.61) | ALDH1A1MAPTKDM4EHSD17B10MEN1 | |
| Maleic Acid SCHEMBL10517643 | 0.76 | ALDH1A1 (0.61) | ALDH1A1MAPTKDM4EHSD17B10MEN1 | |
| Fumaric Acid SCHEMBL10520700 | 0.74 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EHSD17B10MEN1 | |
| Fumaric Acid SCHEMBL10520711 | 0.74 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0183191-B1 | THIENYLTHIAZOLE COMPOUNDS | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-05-10 | — | — | EP | disclosed |
| US-4720493-A | Thienylthiazole compounds | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1988-01-19 | — | — | US | disclosed |
| EP-0183191-A1 | Thienylthiazole compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1986-06-04 | — | — | EP | disclosed |