Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A known ✓ | Q03164 | 5/20 | 0.53 |
| ▸ | ATP4A known ✓ | P20648 | 1/20 | 0.33 |
| ▸ | ATP4B known ✓ | P51164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM4B | O94953 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10520711 | 1.00 | ALDH1A1 (0.53) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL10520394 | 0.89 | ALDH1A1 (0.54) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| Maleic Acid SCHEMBL10517643 | 0.78 | ALDH1A1 (0.61) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| Fumaric Acid SCHEMBL10517651 | 0.78 | ALDH1A1 (0.61) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| Maleic Acid SCHEMBL10520379 | 0.75 | ALDH1A1 (0.46) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| Fumaric Acid SCHEMBL10520381 | 0.75 | ALDH1A1 (0.46) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| Fumaric Acid SCHEMBL10519990 | 0.74 | ALDH1A1 (0.48) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| Fumaric Acid SCHEMBL10519985 | 0.74 | ALDH1A1 (0.48) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL10621996 | 0.73 | ALDH1A1 (0.58) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| Fumaric Acid SCHEMBL10621886 | 0.73 | ALDH1A1 (0.64) | ALDH1A1MAPTMEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0183191-B1 | THIENYLTHIAZOLE COMPOUNDS | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-05-10 | — | — | EP | disclosed |
| US-4720493-A | Thienylthiazole compounds | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1988-01-19 | — | — | US | disclosed |
| EP-0183191-A1 | Thienylthiazole compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1986-06-04 | — | — | EP | disclosed |