Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 2/20 | 0.50 |
| ▸ | MMP3 | P08254 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 7/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 5/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 5/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 5/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521374 | 0.92 | CAPN1 (0.48) | CAPN1MMP3CTSLCTSBMMP2 | |
| SCHEMBL10519910 | 0.91 | CAPN1 (0.52) | CAPN1MMP3CTSLCTSBERAP2 | |
| SCHEMBL10519808 | 0.90 | CAPN1 (0.52) | CAPN1MMP3CTSLCTSBERAP2 | |
| SCHEMBL10901408 | 0.88 | CAPN1 (0.43) | CAPN1CTSLCTSBMMP1CTSS | |
| SCHEMBL10636543 | 0.87 | CAPN1 (0.51) | CAPN1MMP3CTSLCTSBMMP2 | |
| SCHEMBL10520279 | 0.86 | CAPN1 (0.47) | CAPN1CTSLERAP2ERAP1MMP2 | |
| SCHEMBL10519671 | 0.85 | CAPN1 (0.46) | CAPN1MMP3CTSLERAP2ERAP1 | |
| SCHEMBL10636541 | 0.85 | CTSL (0.59) | CAPN1CTSLCTSBCTSS | |
| SCHEMBL10518929 | 0.84 | REN (0.42) | CAPN1CTSLCTSBERAP2ERAP1 | |
| SCHEMBL10522177 | 0.83 | CAPN1 (0.46) | CAPN1MMP3CTSBMMP2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |