Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 8/20 | 0.46 |
| ▸ | CTSB | P07858 | 4/20 | 0.46 |
| ▸ | MMP9 | P14780 | 6/20 | 0.42 |
| ▸ | MMP2 | P08253 | 5/20 | 0.42 |
| ▸ | MMP8 | P22894 | 5/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.41 |
| ▸ | FCER2 | P06734 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519808 | 0.92 | CAPN1 (0.52) | CAPN1CTSBMMP9MMP2MMP1 | |
| SCHEMBL10519910 | 0.90 | CAPN1 (0.52) | CAPN1CTSBMMP9MMP2MMP1 | |
| SCHEMBL10520279 | 0.86 | CAPN1 (0.47) | CAPN1MMP9MMP2MMP8PSMB5 | |
| SCHEMBL10521374 | 0.85 | CAPN1 (0.48) | CAPN1CTSBMMP9MMP2MMP8 | |
| SCHEMBL10519671 | 0.85 | CAPN1 (0.46) | CAPN1MMP9MMP2MMP8PSMB5 | |
| SCHEMBL10984447 | 0.83 | CTSL (0.53) | CAPN1CTSBPSMB1PSMB5PSMB2 | |
| SCHEMBL10520198 | 0.83 | CAPN1 (0.50) | CAPN1CTSBMMP2MMP1MMP3 | |
| SCHEMBL10636543 | 0.83 | CAPN1 (0.51) | CAPN1CTSBMMP9MMP2MMP8 | |
| SCHEMBL10519730 | 0.79 | MMP2 (0.41) | CAPN1CTSBMMP9MMP2MMP8 | |
| SCHEMBL10636541 | 0.78 | CTSL (0.59) | CAPN1CTSBPSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |