Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 2/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10522083 | 0.88 | HRH4 (0.45) | HRH4ANPEPERAP2ERAP1KMT2A | |
| SCHEMBL10520319 | 0.88 | HRH4 (0.44) | HRH4ANPEPERAP2ERAP1MMP1 | |
| SCHEMBL10570975 | 0.87 | HRH4 (0.47) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL10570967 | 0.87 | HRH4 (0.47) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL8481391 | 0.84 | HRH4 (0.64) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL8481380 | 0.84 | HRH4 (0.64) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL10826534 | 0.84 | MMP1 (0.48) | MMEACECPA1ACE2MMP1 | |
| SCHEMBL8481892 | 0.84 | HRH4 (0.56) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL8481399 | 0.84 | HRH4 (0.56) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL8481408 | 0.84 | HRH4 (0.56) | HRH4MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |