Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 6/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 6/20 | 0.39 |
| ▸ | MMP8 | P22894 | 5/20 | 0.39 |
| ▸ | MMP14 | P50281 | 4/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | MMP11 | P24347 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520319 | 0.89 | HRH4 (0.44) | HRH4MMP9MMP1MMP3MMP2 | |
| SCHEMBL10521239 | 0.88 | HRH4 (0.48) | HRH4MMP9MMP1MMP3MMP2 | |
| SCHEMBL10522999 | 0.86 | KMT2A (0.44) | HRH4MMP9MMP1MMP3MMP2 | |
| SCHEMBL10521500 | 0.86 | REN (0.44) | HRH4MMP9MMP2MMP8ANPEP | |
| SCHEMBL10520279 | 0.85 | CAPN1 (0.47) | HRH4MMP9MMP1MMP2MMP8 | |
| SCHEMBL10519671 | 0.85 | CAPN1 (0.46) | HRH4MMP9MMP1MMP3MMP2 | |
| SCHEMBL10522370 | 0.83 | REN (0.44) | HRH4MMP9MMP1MMP2MMP8 | |
| SCHEMBL8487752 | 0.83 | HRH4 (0.48) | HRH4CTSSCTSK | |
| SCHEMBL8487755 | 0.83 | HRH4 (0.48) | HRH4CTSSCTSK | |
| SCHEMBL10639324 | 0.82 | REN (0.52) | HRH4CTSSCTSKREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |