Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24928346 | 0.84 | MEN1 (0.46) | MEN1GAAKMT2ACA1KCNA5 | |
| SCHEMBL7265384 | 0.74 | HPGD (0.38) | MEN1KMT2A | |
| SCHEMBL21582671 | 0.70 | MEN1 (0.39) | MEN1GAAKMT2ACA1KCNA5 | |
| SCHEMBL23354478 | 0.69 | CYP2D6 (0.48) | CA1 | |
| SCHEMBL31466178 | 0.68 | CYP2D6 (0.39) | MEN1GAAKMT2ACA1 | |
| SCHEMBL16153117 | 0.68 | RIPK1 (0.39) | CA1 | |
| SCHEMBL13306481 | 0.66 | TDP1 (0.46) | MEN1GAAKMT2ACA1 | |
| SCHEMBL19750462 | 0.66 | RECQL (0.44) | MEN1GAAKMT2ACA1 | |
| SCHEMBL3686909 | 0.65 | TDP1 (0.44) | MEN1GAAKMT2ACA1 | |
| SCHEMBL8535486 | 0.65 | TDP1 (0.53) | MEN1GAAKMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4829053-A | Amino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1989-05-09 | — | — | US | disclosed |
| EP-0262318-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1988-04-06 | — | — | EP | disclosed |