Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.40 |
| ▸ | HTR3B | O95264 | 3/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597521 | 0.90 | HTR3A (0.34) | HTR3ACYP3A4KCNH2CYP1A2HTR2B | |
| SCHEMBL9597379 | 0.89 | HTR3A (0.33) | HTR3ACYP3A4KCNH2CYP1A2HTR2B | |
| SCHEMBL9596742 | 0.88 | HTR3A (0.38) | HTR3ACYP3A4KCNH2CYP1A2HTR2B | |
| SCHEMBL9597424 | 0.88 | HTR3A (0.33) | HTR3ACYP3A4KCNH2CYP1A2HTR2B | |
| SCHEMBL9597678 | 0.88 | HTR3A (0.38) | HTR3ACYP3A4KCNH2CYP1A2HTR2B | |
| SCHEMBL9596524 | 0.88 | HTR3A (0.36) | HTR3ACYP3A4KCNH2CYP1A2HTR2B | |
| SCHEMBL9597348 | 0.88 | HTR3A (0.36) | HTR3ACYP3A4KCNH2CYP1A2HTR2B | |
| SCHEMBL9597198 | 0.87 | HTR3A (0.35) | HTR3ACYP3A4KCNH2CYP1A2HTR2B | |
| SCHEMBL9596051 | 0.87 | P2RX7 (0.34) | HTR3ACYP3A4KCNH2CYP1A2HTR2B | |
| SCHEMBL9597016 | 0.86 | HTR6 (0.36) | HTR3ACYP3A4KCNH2CYP1A2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4859662-A | Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances | GLAXO GROUP LIMITED (GB) | 1989-08-22 | — | — | US | disclosed |
| US-4822881-A | PSYCHOTIC DISORDERS, ANXIETY, NAUSEA, VOMITING | GLAXO GROUP LIMITED | 1989-04-18 | — | — | US | disclosed |