Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.46 |
| ▸ | MMP1 | P03956 | 4/20 | 0.44 |
| ▸ | MMP3 | P08254 | 3/20 | 0.41 |
| ▸ | MMP8 | P22894 | 5/20 | 0.40 |
| ▸ | MMP9 | P14780 | 4/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520294 | 0.91 | REN (0.42) | RENMMP8MMP9MMP2 | |
| SCHEMBL10522370 | 0.91 | REN (0.44) | RENMMP1MMP8MMP9MMP2 | |
| SCHEMBL10521500 | 0.90 | REN (0.44) | RENMMP8MMP9MMP2HRH4 | |
| SCHEMBL10524040 | 0.89 | REN (0.44) | RENMMP1MMP8MMP9MMP2 | |
| SCHEMBL10633366 | 0.87 | REN (0.58) | RENMMP8MMP9CTSBCTSK | |
| SCHEMBL10976366 | 0.87 | REN (0.58) | RENMMP8MMP9CTSBCTSK | |
| SCHEMBL10636529 | 0.87 | REN (0.58) | RENMMP8MMP9CTSBCTSK | |
| SCHEMBL10981168 | 0.87 | REN (0.58) | RENMMP8MMP9CTSBCTSK | |
| SCHEMBL10523699 | 0.86 | MMP2 (0.41) | RENMMP8MMP9MMP2 | |
| SCHEMBL10636517 | 0.84 | REN (0.56) | RENMMP8MMP9CTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |