Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 4/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 4/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | IL1RN | P18510 | 2/20 | 0.38 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10522370 | 0.91 | REN (0.44) | RENMMP9MMP8HRH4MMP2 | |
| SCHEMBL10521500 | 0.91 | REN (0.44) | RENMMP9MMP8HRH4MMP2 | |
| SCHEMBL10522201 | 0.89 | REN (0.46) | RENMMP9MMP8HRH4MMP2 | |
| SCHEMBL10518929 | 0.89 | REN (0.42) | RENMMP9MMP8HRH4MMP2 | |
| SCHEMBL10520294 | 0.88 | REN (0.42) | RENMMP9MMP8MMP2ERAP2 | |
| SCHEMBL10522717 | 0.86 | REN (0.41) | RENMMP9MMP8HRH4MMP2 | |
| SCHEMBL10521511 | 0.86 | MMP2 (0.46) | RENMMP9MMP8MMP2 | |
| SCHEMBL10519796 | 0.85 | MMP9 (0.47) | RENMMP9MMP8MMP2MMP1 | |
| SCHEMBL10633366 | 0.84 | REN (0.58) | RENMMP9MMP8ERAP2ERAP1 | |
| SCHEMBL10636529 | 0.84 | REN (0.58) | RENMMP9MMP8ERAP2ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |