Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5520683 | 0.86 | DRD2 (0.59) | DRD2HTR2AHTR2BPKMALDH1A1 | |
| SCHEMBL14889779 | 0.79 | POLB (0.56) | DRD2HTR2AHTR2BPKMALDH1A1 | |
| SCHEMBL11175703 | 0.79 | POLB (0.46) | DRD2HTR2AHTR2BPKMALDH1A1 | |
| SCHEMBL29383617 | 0.79 | MAPK1 (0.58) | DRD2HTR2AHTR2BPKML3MBTL1 | |
| SCHEMBL5520212 | 0.79 | MAPK1 (0.58) | DRD2HTR2AHTR2BPKML3MBTL1 | |
| SCHEMBL11177255 | 0.78 | CYP1A2 (0.42) | POLBKMT2AMEN1CYP1A2LMNA | |
| SCHEMBL8682011 | 0.78 | GAA (0.60) | DRD2HTR2AHTR2BPKMALDH1A1 | |
| SCHEMBL30409645 | 0.78 | DRD2 (0.51) | DRD2HTR2AHTR2BPKMALDH1A1 | |
| SCHEMBL5518653 | 0.76 | NLRP3 (0.57) | ALDH1A1POLBKMT2AMEN1MAPT | |
| Urea SCHEMBL27832370 | 0.76 | MAPT (0.43) | DRD2HTR2AHTR2BPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4808752-A | REACTING 2-AMINOBENZOTHIAZOLES WITH ALKALI HYDROXIDES; ALKYLATING AND HYDROLYZING THE RESULTING MERCAPTOPHENYLUREA SALT | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-28 | — | — | US | disclosed |
| US-4727154-A | ACRYLATION 2-MERCAPTOPHENYLUREA | HOECHST AKTIENGESELLSCHAFT | 1988-02-23 | — | — | US | disclosed |
| US-4370483-A | ACIDIFICATION TO EFFECT CYCLIZATION OF AN O-MERCAPTO-N-PHENYLUREA OBTAINED BY HYDROLYSIS OF A 2-HYDROXYBENZOTHIAZOLE | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-01-25 | — | — | US | disclosed |