Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10840248 | 0.65 | MAPK1 (0.44) | FAAHMAPK1MAPTKDM4EALDH1A1 | |
| SCHEMBL6581440 | 0.63 | FAAH (0.58) | FAAHMAPTSMN1; SMN2 | |
| SCHEMBL11332477 | 0.63 | FAAH (0.37) | FAAHMAPK1GHSRKMT2A | |
| SCHEMBL18839755 | 0.62 | MAPK1 (0.44) | MAPK1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL10128478 | 0.62 | MAPK1 (0.41) | FAAHMAPK1MAPTKDM4EALDH1A1 | |
| SCHEMBL11778347 | 0.61 | MAPK1 (0.69) | MAPK1MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11776322 | 0.61 | MAPK1 (0.51) | MAPK1MAPTALDH1A1GAAHPGD | |
| SCHEMBL20128067 | 0.61 | MAPK1 (0.33) | FAAHMAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL20518647 | 0.61 | CA1 (0.38) | FAAHMAPK1MAPTALDH1A1GLA | |
| SCHEMBL18839913 | 0.61 | MAPK1 (0.47) | MAPK1MAPTKDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4829053-A | Amino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1989-05-09 | — | — | US | disclosed |
| EP-0262318-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1988-04-06 | — | — | EP | disclosed |